A Novel Monoclonal Antibody Based Diagnostic Test for a - Thalassemia - 1 Carriers Due to the ( / ) Deletion
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چکیده
The presence of minute amounts of embryonic -globin chains in adult hemolysates is a marker for carriers of a-thalassemia-1 resulting from ( / ) deletion. Recently. we developed a murine monoclonal antihuman embryonic -globin chain antibody, 8E8. By using this antibody. we have now established a slot-blot immunobinding assay for the rapid detection of -globin chains in adult hemolysates. -globin chains were found to be present in 30 blood samples obtained from individuals who were carriers of
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تاریخ انتشار 2005